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COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells

BACKGROUND: Glioblastoma (GBM) is the deadliest and the most common primary brain tumor in adults. The invasiveness and proliferation of GBM cells can be decreased through the inhibition of Wnt/β-catenin pathway. In this regard, celecoxib is a promising agent, but other COXIBs and 2,5-dimethylceleco...

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Dettagli Bibliografici
Pubblicato in:BMC Cancer
Autori principali: Majchrzak-Celińska, Aleksandra, Misiorek, Julia O., Kruhlenia, Nastassia, Przybyl, Lukasz, Kleszcz, Robert, Rolle, Katarzyna, Krajka-Kuźniak, Violetta
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091781/
https://ncbi.nlm.nih.gov/pubmed/33941107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08164-1
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