A neo-substrate that amplifies catalytic activity of Parkinson’s disease related kinase PINK1

Mitochondria have long been implicated in the pathogenesis of Parkinson’s disease (PD). Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with mitochondrial defects and result in an autosomal recessive form of early onset PD. Therapeutic approaches for enhancing...

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Main Authors: Hertz, Nicholas T., Berthet, Amandine, Sos, Martin L., Thorn, Kurt S., Burlingame, Al L., Nakamura, Ken, Shokat, Kevan M.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950538/
https://ncbi.nlm.nih.gov/pubmed/23953109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.030
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