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Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2
Recruitment of circulating leukocytes into inflamed tissues depends on adhesion molecules expressed by endothelial cells (ECs). Here we report that rapamycin pretreatment reduced the ability of TNF-treated ECs to capture T cells under conditions of venular flow. This functional change was caused by...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949571/ https://ncbi.nlm.nih.gov/pubmed/24516119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131125 |
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