Alloantibody and Complement Promote T Cell-Mediated Cardiac Allograft Vasculopathy through Non-Canonical NF-κB Signaling in Endothelial Cells

BACKGROUND: Cardiac allograft vasculopathy (CAV) is the major cause of late allograft loss following heart transplantation. CAV lesions contain alloreactive T cells that secrete IFN-γ, a vasculopathic cytokine, and occur more frequently in patients with donor specific antibody (DSA). Pathologic inte...

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Main Authors: Jane-wit, Dan, Manes, Thomas D., Yi, Tai, Qin, Lingfeng, Clark, Pamela, Kirkiles-Smith, Nancy C., Abrahimi, Parwiz, Devalliere, Julie, Moeckel, Gilbert, Kulkarni, Sanjay, Tellides, George, Pober, Jordan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885874/
https://ncbi.nlm.nih.gov/pubmed/24045046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002972
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