Complement C5 Inhibition Reduces T Cell-Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice

Allograft vasculopathy (AV) is characterized by diffuse stenoses in the vasculature of solid organ transplants. Previously, we developed two humanized models showing that alloantibody and ischemia reperfusion injury (IRI) exacerbated T cell-mediated AV in human arterial xenografts in vivo. Here we e...

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Publicado en:Am J Transplant
Main Authors: Qin, Lingfeng, Li, Guangxin, Kirkiles-Smith, Nancy, Clark, Pamela, Fang, Caodi, Wang, Yi, Yu, Zhao-Xue, Devore, Denise, Tellides, George, Pober, Jordan S, Jane-wit, Dan
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075274/
https://ncbi.nlm.nih.gov/pubmed/27104811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.13834
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