Endothelial Cell-Derived IL-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production

BACKGROUND--: Ischemia reperfusion injury (IRI) predisposes to formation of donor specific antibodies (DSA), a factor contributing to chronic rejection and late allograft loss. METHODS--: We describe a mechanism underlying the correlative association between IRI and DSA using humanized models and pa...

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Publicado no:Circulation
Main Authors: Liu, Lufang, Fang, Caodi, Fu, Whitney, Jiang, Bo, Li, Guangxin, Qin, Lingfeng, Rosenbluth, Jacob, Gong, Gavin, Xie, Catherine B., Yoo, Peter, Tellides, George, Pober, Jordan S., Jane-wit, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035199/
https://ncbi.nlm.nih.gov/pubmed/31744330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.042501
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