ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

Complement promotes vascular inflammation in transplant organ rejection and connective tissue diseases. Here we identify ZFYVE21 as a complement-induced Rab5 effector that induces non-canonical NF-κB in endothelial cells (EC). In response to membrane attack complexes (MAC), ZFYVE21 is post-translati...

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Udgivet i:Nat Commun
Main Authors: Fang, Caodi, Manes, Thomas D., Liu, Lufang, Liu, Kevin, Qin, Lingfeng, Li, Guangxin, Tobiasova, Zuzana, Kirkiles-Smith, Nancy C., Patel, Manal, Merola, Jonathan, Fu, Whitney, Liu, Rebecca, Xie, Catherine, Tietjen, Gregory T., Nigrovic, Peter A., Tellides, George, Pober, Jordan S., Jane-wit, Dan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529429/
https://ncbi.nlm.nih.gov/pubmed/31113953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10041-2
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