Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt(+)NIK(+) signalosome on Rab5(+) endosomes

Complement membrane attack complexes (MACs) promote inflammatory functions in endothelial cells (ECs) by stabilizing NF-κB–inducing kinase (NIK) and activating noncanonical NF-κB signaling. Here we report a novel endosome-based signaling complex induced by MACs to stabilize NIK. We found that, in co...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Jane-wit, Dan, Surovtseva, Yulia V., Qin, Lingfeng, Li, Guangxin, Liu, Rebecca, Clark, Pamela, Manes, Thomas D., Wang, Chen, Kashgarian, Michael, Kirkiles-Smith, Nancy C., Tellides, George, Pober, Jordan S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534258/
https://ncbi.nlm.nih.gov/pubmed/26195760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503535112
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