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Complement-activated interferon-γ–primed human endothelium transpresents interleukin-15 to CD8(+) T cells
Alloantibodies in presensitized transplant candidates deposit complement membrane attack complexes (MACs) on graft endothelial cells (ECs), increasing risk of CD8(+) T cell–mediated acute rejection. We recently showed that human ECs endocytose MACs into Rab5(+) endosomes, creating a signaling platfo...
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| Veröffentlicht in: | J Clin Invest |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7324183/ https://ncbi.nlm.nih.gov/pubmed/32191642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135060 |
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