Complement-activated interferon-γ–primed human endothelium transpresents interleukin-15 to CD8(+) T cells

Alloantibodies in presensitized transplant candidates deposit complement membrane attack complexes (MACs) on graft endothelial cells (ECs), increasing risk of CD8(+) T cell–mediated acute rejection. We recently showed that human ECs endocytose MACs into Rab5(+) endosomes, creating a signaling platfo...

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Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Xie, Catherine B., Jiang, Bo, Qin, Lingfeng, Tellides, George, Kirkiles-Smith, Nancy C., Jane-wit, Dan, Pober, Jordan S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324183/
https://ncbi.nlm.nih.gov/pubmed/32191642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135060
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