Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells

Human graft endothelial cells (ECs) can act as antigen-presenting cells to initiate allograft rejection by host memory T cells. Rapamycin, an mTOR inhibitor used clinically to suppress T cell responses, also acts on DCs, rendering them tolerogenic. Here, we report the effects of rapamycin on EC allo...

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Detalhes bibliográficos
Main Authors: Wang, Chen, Yi, Tai, Qin, Lingfeng, Maldonado, Roberto A., von Andrian, Ulrich H., Kulkarni, Sanjay, Tellides, George, Pober, Jordan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613923/
https://ncbi.nlm.nih.gov/pubmed/23478407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66204
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