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Deletion of α-subunit exon 11 of the epithelial Na(+) channel reveals a regulatory module

Epithelial Na(+) channel (ENaC) subunits (α, β, and γ) found in functional complexes are translated from mature mRNAs that are similarly processed by the inclusion of 13 canonical exons. We examined whether individual exons 3–12, encoding the large extracellular domain, are required for functional c...

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Main Authors: Chen, Jingxin, Kleyman, Thomas R., Sheng, Shaohu
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949035/
https://ncbi.nlm.nih.gov/pubmed/24402098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00587.2013
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