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Energetic analysis of the R*-G complex links the α5 helix to GDP release and domain opening
We present a model of interaction of G(i) protein with activated rhodopsin (R*) which pin-points energetic contributions to activation and reconciles the β(2)AR–G(s) crystal structure with new and previously published experimental data. In silico analysis demonstrated energetic changes when the Gα C...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947367/ https://ncbi.nlm.nih.gov/pubmed/24292645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2705 |
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