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Helix dipole movement and conformational variability contribute to allosteric GDP release in Gα(i) subunits
Heterotrimeric G proteins (Gαβγ) transmit signals from activated G protein coupled receptors (GPCRs) to downstream effectors through a guanine nucleotide signaling cycle. Numerous studies indicate that the carboxy-terminal α5 helix of Gα subunits participate in Gα-receptor binding, and previous EPR...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736342/ https://ncbi.nlm.nih.gov/pubmed/19222191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801853a |
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