Helix dipole movement and conformational variability contribute to allosteric GDP release in Gα(i) subunits

Heterotrimeric G proteins (Gαβγ) transmit signals from activated G protein coupled receptors (GPCRs) to downstream effectors through a guanine nucleotide signaling cycle. Numerous studies indicate that the carboxy-terminal α5 helix of Gα subunits participate in Gα-receptor binding, and previous EPR...

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Autors principals: Preininger, Anita M., Funk, Michael A., Meier, Scott M., Oldham, William M., Johnston, Christopher A., Adhikary, Suraj, Kimple, Adam J., Siderovski, David P., Hamm, Heidi E., Iverson, Tina M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736342/
https://ncbi.nlm.nih.gov/pubmed/19222191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801853a
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