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Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution
Coupling of heterotrimeric G proteins to activated G protein-coupled receptors results in nucleotide exchange on the Gα subunit, which in turn decreases its affinity for both Gβγ and activated receptors. N-terminal myristoylation of Gα subunits aids in membrane localization of inactive G proteins. D...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3312377/ https://ncbi.nlm.nih.gov/pubmed/22329346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201472c |
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