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Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution

Coupling of heterotrimeric G proteins to activated G protein-coupled receptors results in nucleotide exchange on the Gα subunit, which in turn decreases its affinity for both Gβγ and activated receptors. N-terminal myristoylation of Gα subunits aids in membrane localization of inactive G proteins. D...

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Main Authors: Preininger, Anita M., Kaya, Ali I., Gilbert, James A., Busenlehner, Laura S., Armstrong, Richard N., Hamm, Heidi E.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312377/
https://ncbi.nlm.nih.gov/pubmed/22329346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201472c
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