A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric G(i) Protein α Subunit

G protein activation by G protein-coupled receptors is one of the critical steps for many cellular signal transduction pathways. Previously, we and other groups reported that the α5 helix in the G protein α subunit plays a major role during this activation process. However, the precise signaling pat...

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Bibliografiske detaljer
Main Authors: Kaya, Ali I., Lokits, Alyssa D., Gilbert, James A., Iverson, Tina M., Meiler, Jens, Hamm, Heidi E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148873/
https://ncbi.nlm.nih.gov/pubmed/25037222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572875
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