Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family G proteins comprise Gq, G11, G14, and G16, which upon activation mediate their cellular effects via inositol lip...

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Udgivet i:J Biol Chem
Main Authors: Malfacini, Davide, Patt, Julian, Annala, Suvi, Harpsøe, Kasper, Eryilmaz, Funda, Reher, Raphael, Crüsemann, Max, Hanke, Wiebke, Zhang, Hang, Tietze, Daniel, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian, König, Gabriele M., Inoue, Asuka, Gomeza, Jesus, Kostenis, Evi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463727/
https://ncbi.nlm.nih.gov/pubmed/30745359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007250
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