MEK targeting in N-RAS mutated metastatic melanoma

BACKGROUND: Gain of function mutations in B-RAF and N-RAS occur frequently in melanoma, leading to mitogen activating protein kinase (MAPK) pathway activation, and this pathway is the target of drugs in development. Our purpose was to study clinical characteristics of patients with mutations in this...

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Bibliographic Details
Main Authors: Thumar, Jaykumar, Shahbazian, David, Aziz, Saadia A, Jilaveanu, Lucia B, Kluger, Harriet M
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945937/
https://ncbi.nlm.nih.gov/pubmed/24588908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-45
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