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Vertical targeting of the phosphatidylinositol-3 kinase (PI3K) pathway as a strategy for treating melanoma

PURPOSE: Melanoma is relatively resistant to chemotherapy; improved targeting of molecules critical for cell proliferation and survival are needed. PI3K is an important target in melanoma, however activity of PI3K inhibitors (PI3KIs) is limited. Our purpose was to assess mTOR as a co-target for PI3K...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Aziz, Saadia A., Jilaveanu, Lucia B., Zito, Christopher, Camp, Robert L., Rimm, David L., Conrad, Patricia, Kluger, Harriet M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058635/
https://ncbi.nlm.nih.gov/pubmed/21169255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1490
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