Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

BACKGROUND: PI3K and mTOR are key components of signal transduction pathways critical for cell survival. Numerous PI3K inhibitors have entered clinical trials, while mTOR is the target of approved drugs for metastatic renal cell carcinoma (RCC). We characterized expression of p85 and p110α PI3K subu...

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Detalhes bibliográficos
Main Authors: Elfiky, Aymen A, Aziz, Saadia A, Conrad, Patricia J, Siddiqui, Summar, Hackl, Wolfgang, Maira, Michel, Robert, Camp L, Kluger, Harriet M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173341/
https://ncbi.nlm.nih.gov/pubmed/21834980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-133
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