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Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors
A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic factor (BDNF). These are the natural ligands for...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3945644/ https://ncbi.nlm.nih.gov/pubmed/24603864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089617 |
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