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Rare variants in BMP2 and BMP4 found in otosclerosis patients reduce Smad signaling

HYPOTHESIS: Genetic variation in BMP2 and BMP4 found in otosclerosis patients result in altered Smad signaling. BACKGROUND: Otosclerosis is a common form of adult-onset conductive hearing loss resulting from abnormal bone remodeling of the bony labyrinth that surrounds the inner ear. Both genetic an...

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Hlavní autoři: Ealy, Megan, Meyer, Nicole C., Corchado, Johnny Cruz, Schrauwen, Isabelle, Bress, Andreas, Pfister, Markus, Van Camp, Guy, Smith, Richard JH
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945298/
https://ncbi.nlm.nih.gov/pubmed/24492129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAO.0000000000000244
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