Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling

Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as insoluble cue physically bound to a biomimetic matrix, called here matrix-bound (bBMP-...

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Vydáno v:Acta Biomater
Hlavní autoři: Gilde, Flora, Fourel, Laure, Guillot, Raphael, Pignot-Paintrand, Isabelle, Okada, Takaharu, Fitzpatrick, Vincent, Boudou, Thomas, Albiges-Rizo, Corinne, Picart, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113753/
https://ncbi.nlm.nih.gov/pubmed/27633320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2016.09.014
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