β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner

Understanding how cells integrate multiple signaling pathways to achieve specific cell differentiation is a challenging question in cell biology. We have explored the physiological presentation of BMP-2 by using a biomaterial that harbors tunable mechanical properties to promote localized BMP-2 sign...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Fourel, Laure, Valat, Anne, Faurobert, Eva, Guillot, Raphael, Bourrin-Reynard, Ingrid, Ren, Kefeng, Lafanechère, Laurence, Planus, Emmanuelle, Picart, Catherine, Albiges-Rizo, Corinne
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792076/
https://ncbi.nlm.nih.gov/pubmed/26953352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201508018
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