Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling

Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as insoluble cue physically bound to a biomimetic matrix, called here matrix-bound (bBMP-...

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Dettagli Bibliografici
Pubblicato in:Acta Biomater
Autori principali: Gilde, Flora, Fourel, Laure, Guillot, Raphael, Pignot-Paintrand, Isabelle, Okada, Takaharu, Fitzpatrick, Vincent, Boudou, Thomas, Albiges-Rizo, Corinne, Picart, Catherine
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113753/
https://ncbi.nlm.nih.gov/pubmed/27633320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2016.09.014
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