EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss

PURPOSE: Chimeric antigen receptor (CAR) transduced T cells represent a promising immune therapy that has been shown to successfully treat cancers in mice and humans. However, CARs targeting antigens expressed in both tumors and normal tissues have led to significant toxicity. Preclinical studies ha...

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Detalhes bibliográficos
Main Authors: Sampson, John H., Choi, Bryan D., Sanchez-Perez, Luis, Suryadevara, Carter M., Snyder, David J., Flores, Catherine T., Schmittling, Robert J., Nair, Smita, Reap, Elizabeth A., Norberg, Pamela K., Herndon, James E., Kuan, Chien-Tsun, Morgan, Richard A., Rosenberg, Steven A., Johnson, Laura A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943170/
https://ncbi.nlm.nih.gov/pubmed/24352643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0709
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