Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis

Epidermal growth factor receptor variant III (EGFRvIII) is a glycoprotein uniquely expressed in glioblastoma, but not in normal brain tissues. To develop targeted therapies for brain tumors, we selected RNA aptamers against the histidine-tagged EGFRvIII ectodomain, using an Escherichia coli system f...

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Hauptverfasser: Liu, Yingmiao, Kuan, Chien-Tsun, Mi, Jing, Zhang, Xiuwu, Clary, Bryan M., Bigner, Darell D., Sullenger, Bruce A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816755/
https://ncbi.nlm.nih.gov/pubmed/19040357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2009.022
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