Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Imp...

Full description

Saved in:
Bibliographic Details
Main Authors: Choi, Bryan D., Suryadevara, Carter M., Gedeon, Patrick C., Herndon, James E., Sanchez-Perez, Luis, Sampson, John H.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867597/
https://ncbi.nlm.nih.gov/pubmed/24054399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jocn.2013.03.012
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items