EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss

PURPOSE: Chimeric antigen receptor (CAR) transduced T cells represent a promising immune therapy that has been shown to successfully treat cancers in mice and humans. However, CARs targeting antigens expressed in both tumors and normal tissues have led to significant toxicity. Preclinical studies ha...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Sampson, John H., Choi, Bryan D., Sanchez-Perez, Luis, Suryadevara, Carter M., Snyder, David J., Flores, Catherine T., Schmittling, Robert J., Nair, Smita, Reap, Elizabeth A., Norberg, Pamela K., Herndon, James E., Kuan, Chien-Tsun, Morgan, Richard A., Rosenberg, Steven A., Johnson, Laura A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943170/
https://ncbi.nlm.nih.gov/pubmed/24352643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0709
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi