EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss

PURPOSE: Chimeric antigen receptor (CAR) transduced T cells represent a promising immune therapy that has been shown to successfully treat cancers in mice and humans. However, CARs targeting antigens expressed in both tumors and normal tissues have led to significant toxicity. Preclinical studies ha...

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Bibliografski detalji
Glavni autori: Sampson, John H., Choi, Bryan D., Sanchez-Perez, Luis, Suryadevara, Carter M., Snyder, David J., Flores, Catherine T., Schmittling, Robert J., Nair, Smita, Reap, Elizabeth A., Norberg, Pamela K., Herndon, James E., Kuan, Chien-Tsun, Morgan, Richard A., Rosenberg, Steven A., Johnson, Laura A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943170/
https://ncbi.nlm.nih.gov/pubmed/24352643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0709
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