EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss

PURPOSE: Chimeric antigen receptor (CAR) transduced T cells represent a promising immune therapy that has been shown to successfully treat cancers in mice and humans. However, CARs targeting antigens expressed in both tumors and normal tissues have led to significant toxicity. Preclinical studies ha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sampson, John H., Choi, Bryan D., Sanchez-Perez, Luis, Suryadevara, Carter M., Snyder, David J., Flores, Catherine T., Schmittling, Robert J., Nair, Smita, Reap, Elizabeth A., Norberg, Pamela K., Herndon, James E., Kuan, Chien-Tsun, Morgan, Richard A., Rosenberg, Steven A., Johnson, Laura A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943170/
https://ncbi.nlm.nih.gov/pubmed/24352643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0709
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