Neutrophil Activation During Acetaminophen Hepatotoxicity and Repair in Mice and Humans

Following acetaminophen (APAP) overdose there is an inflammatory response triggered by release of cellular contents from necrotic hepatocytes into systemic circulation which initiates the recruitment of neutrophils into the liver. It has been demonstrated that neutrophils do not contribute to APAP-i...

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Hauptverfasser: Williams, C. David, Bajt, Mary Lynn, Sharpe, Matthew R., McGill, Mitchell R., Farhood, Anwar, Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941640/
https://ncbi.nlm.nih.gov/pubmed/24440789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2014.01.004
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