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Fas Receptor-deficient lpr Mice are protected against Acetaminophen Hepatotoxicity due to Higher Glutathione Synthesis and Enhanced Detoxification of Oxidant Stress

Acetaminophen (APAP) overdose is a classical model of hepatocellular necrosis; however, the involvement of the Fas receptor in the pathophysiology remains controversial. Fas receptor-deficient (lpr) and C57BL/6 mice were treated with APAP to compare the mechanisms of hepatotoxicity. Lpr mice were pa...

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Autori principali: Williams, C. David, McGill, Mitchell R., Farhood, Anwar, Jaeschke, Hartmut
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703493/
https://ncbi.nlm.nih.gov/pubmed/23628456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2013.04.031
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