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Molecular Determinants of Allosteric Modulation at the M(1) Muscarinic Acetylcholine Receptor
Benzylquinolone carboxylic acid (BQCA) is an unprecedented example of a selective positive allosteric modulator of acetylcholine at the M(1) muscarinic acetylcholine receptor (mAChR). To probe the structural basis underlying its selectivity, we utilized site-directed mutagenesis, analytical modeling...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937673/ https://ncbi.nlm.nih.gov/pubmed/24443568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.539080 |
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