Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR...

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Hlavní autoři: Balland, Eglantine, Dam, Julie, Langlet, Fanny, Caron, Emilie, Steculorum, Sophie, Messina, Andrea, Rasika, S, Falluel-Morel, Anthony, Anouar, Youssef, Dehouck, Bénédicte, Trinquet, Eric, Jockers, Ralf, Bouret, Sebastien G, Prévot, Vincent
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936883/
https://ncbi.nlm.nih.gov/pubmed/24506870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.12.015
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