Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR...

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Библиографические подробности
Главные авторы: Balland, Eglantine, Dam, Julie, Langlet, Fanny, Caron, Emilie, Steculorum, Sophie, Messina, Andrea, Rasika, S, Falluel-Morel, Anthony, Anouar, Youssef, Dehouck, Bénédicte, Trinquet, Eric, Jockers, Ralf, Bouret, Sebastien G, Prévot, Vincent
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936883/
https://ncbi.nlm.nih.gov/pubmed/24506870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.12.015
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