Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR...

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Bibliografski detalji
Glavni autori: Balland, Eglantine, Dam, Julie, Langlet, Fanny, Caron, Emilie, Steculorum, Sophie, Messina, Andrea, Rasika, S, Falluel-Morel, Anthony, Anouar, Youssef, Dehouck, Bénédicte, Trinquet, Eric, Jockers, Ralf, Bouret, Sebastien G, Prévot, Vincent
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936883/
https://ncbi.nlm.nih.gov/pubmed/24506870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.12.015
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