Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR...

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Detalhes bibliográficos
Main Authors: Balland, Eglantine, Dam, Julie, Langlet, Fanny, Caron, Emilie, Steculorum, Sophie, Messina, Andrea, Rasika, S, Falluel-Morel, Anthony, Anouar, Youssef, Dehouck, Bénédicte, Trinquet, Eric, Jockers, Ralf, Bouret, Sebastien G, Prévot, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936883/
https://ncbi.nlm.nih.gov/pubmed/24506870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.12.015
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