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Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936883/ https://ncbi.nlm.nih.gov/pubmed/24506870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.12.015 |
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