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Focused Ultrasound-Mediated Drug Delivery from Microbubbles Reduces Drug Dose Necessary for Therapeutic Effect on Neointima Formation

OBJECTIVE: We hypothesized that 1) neointimal formation in a rat carotid balloon injury model could be reduced in vivo following targeted ultrasound delivery of rapamycin-loaded microbubbles (RMBs), and 2) the addition of dual mode ultrasound decreases the total amount of drug needed to reduce neoin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Phillips, Linsey C., Dhanaliwala, Ali H., Klibanov, Alexander L., Hossack, John A., Wamhoff, Brian R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935345/
https://ncbi.nlm.nih.gov/pubmed/21960561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.238170
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