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Localized Ultrasound Enhances Delivery of Rapamycin from Microbubbles to Prevent Smooth Muscle Proliferation

Microbubble contrast agents have been shown to enhance reagent delivery when activated by ultrasound. We hypothesized that ultrasound would enhance delivery of rapamycin, an antiproliferative agent, from the shell of microbubbles, thus reducing proliferation of vascular smooth muscle cells. Our obje...

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Bibliografiske detaljer
Main Authors: Phillips, Linsey C., Klibanov, Alexander L., Wamhoff, Brian R., Hossack, John A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148278/
https://ncbi.nlm.nih.gov/pubmed/21549778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.04.020
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