Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells

The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with clinically relevant chemotherapies to kill gastrointestinal/genitourinary cancer cells. In bladder cancer cells, regardless of H-RAS mutational status, at clinically achievable doses, PDE...

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Main Authors: Booth, Laurence, Roberts, Jane L., Cruickshanks, Nichola, Conley, Adam, Durrant, David E., Das, Anindita, Fisher, Paul B., Kukreja, Rakesh C., Grant, Steven, Poklepovic, Andrew, Dent, Paul
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935155/
https://ncbi.nlm.nih.gov/pubmed/24353313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.090043
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