Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

We determined whether the multi‐kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over‐expressed in liver tumors compared to normal liver tissue. In multiple cell type...

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Bibliografiske detaljer
Udgivet i:J Cell Physiol
Main Authors: Tavallai, Mehrad, Hamed, Hossein A., Roberts, Jane L., Cruickshanks, Nichola, Chuckalovcak, John, Poklepovic, Andrew, Booth, Laurence, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835179/
https://ncbi.nlm.nih.gov/pubmed/25704960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24961
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