GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases

Prior tumor cell studies have shown that the drugs sorafenib (Nexavar) and regorafenib (Stivarga) reduce expression of the chaperone GRP78. Sorafenib/regorafenib and the multi‐kinase inhibitor pazopanib (Votrient) interacted with sildenafil (Viagra) to further rapidly reduce GRP78 levels in eukaryot...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Roberts, Jane L., Tavallai, Mehrad, Nourbakhsh, Aida, Fidanza, Abigail, Cruz‐Luna, Tanya, Smith, Elizabeth, Siembida, Paul, Plamondon, Pascale, Cycon, Kelly A., Doern, Christopher D., Booth, Laurence, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843173/
https://ncbi.nlm.nih.gov/pubmed/25858032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25014
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