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AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication
AR12 is a derivative of celecoxib which no-longer acts against COX2 but instead inhibits the ATPase activity of multiple chaperone proteins, in particular GRP78. GRP78 acts as a sensor of endoplasmic reticulum stress and is an essential chaperone required for the life cycle of all mammalian viruses....
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| 出版年: | Biochem Pharmacol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier Inc.
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7502229/ https://ncbi.nlm.nih.gov/pubmed/32966814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114227 |
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