Sorafenib/Regorafenib and Phosphatidyl Inositol 3 Kinase/Thymoma Viral Proto-Oncogene Inhibition Interact to Kill Tumor Cells

The present studies were undertaken to determine whether the multikinase inhibitors sorafenib/regorafenib cooperated with clinically relevant , phosphatidyl inositol 3 kinase (PI3K)-thymoma viral proto-oncogene (AKT) inhibitors to kill tumor cells. In liver, colorectal, lung, breast, kidney, and bra...

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Main Authors: Sajithlal, Gangadharan B., Hamed, Hossein A., Cruickshanks, Nichola, Booth, Laurence, Tavallai, Seyedmehrad, Syed, Jahangir, Grant, Steven, Poklepovic, Andrew, Dent, Paul
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781387/
https://ncbi.nlm.nih.gov/pubmed/23877009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.088005
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