Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

The present studies focused on defining the mechanisms by which anoikis-resistant (AR) mammary carcinoma cells can be reverted to a therapy-sensitive phenotype. AR mammary carcinoma cells had reduced expression of the toxic BH3 domain proteins BAX, BAK, NOXA, and PUMA. In AR cells expression of the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Cruickshanks, Nichola, Hamed, Hossein A, Booth, Laurence, Tavallai, Seyedmehrad, Syed, Jahangir, Sajithlal, Gangadharan B, Grant, Steven, Poklepovic, Andrew, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926895/
https://ncbi.nlm.nih.gov/pubmed/24025251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26234
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados