Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

The present studies focused on defining the mechanisms by which anoikis-resistant (AR) mammary carcinoma cells can be reverted to a therapy-sensitive phenotype. AR mammary carcinoma cells had reduced expression of the toxic BH3 domain proteins BAX, BAK, NOXA, and PUMA. In AR cells expression of the...

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Main Authors: Cruickshanks, Nichola, Hamed, Hossein A, Booth, Laurence, Tavallai, Seyedmehrad, Syed, Jahangir, Sajithlal, Gangadharan B, Grant, Steven, Poklepovic, Andrew, Dent, Paul
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926895/
https://ncbi.nlm.nih.gov/pubmed/24025251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26234
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