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The ABCA1 domain responsible for interaction with HIV-1 Nef is conformational and not linear

HIV-1 Nef is an accessory protein responsible for inactivation of a number of host cell proteins essential for anti-viral immune responses. In most cases, Nef binds to the target protein and directs it to a degradation pathway. Our previous studies demonstrated that Nef impairs activity of the cellu...

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Hlavní autoři: Jacob, Daria, Hunegnaw, Ruth, Sabyrzyanova, Tatyana A., Pushkarsky, Tatiana, Chekhov, Vladimir O., Adzhubei, Alexei A., Kalebina, Tatyana S., Bukrinsky, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934640/
https://ncbi.nlm.nih.gov/pubmed/24406162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.12.141
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