Interaction between HIV-1 Nef and calnexin: from modeling to small molecule inhibitors reversing HIV-induced lipid accumulation

OBJECTIVE: HIV-infected patients are at an increased risk of developing atherosclerosis, in part due to downmodulation and functional impairment of ATP-Binding Cassette A1 (ABCA1) cholesterol transporter by the HIV-1 protein Nef. The mechanism of this effect involves Nef interacting with an endoplas...

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Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Hunegnaw, Ruth, Vassylyeva, Marina, Dubrovsky, Larisa, Pushkarsky, Tatiana, Sviridov, Dmitri, Anashkina, Anastasia A., Üren, Aykut, Brichacek, Beda, Vassylyev, Dmitry, Adzhubei, Alexei A., Bukrinsky, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040351/
https://ncbi.nlm.nih.gov/pubmed/27470515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307997
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