Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

Melanomas that result from mutations in the gene encoding BRAF often become resistant to BRAF inhibition (BRAFi), with multiple mechanisms contributing to resistance. While therapy-induced autophagy promotes resistance to a number of therapies, especially those that target PI3K/mTOR signaling, its r...

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Autors principals: Ma, Xiao-Hong, Piao, Sheng-Fu, Dey, Souvik, Mcafee, Quentin, Karakousis, Giorgos, Villanueva, Jessie, Hart, Lori S., Levi, Samuel, Hu, Janice, Zhang, Gao, Lazova, Rossitza, Klump, Vincent, Pawelek, John M., Xu, Xiaowei, Xu, Wei, Schuchter, Lynn M., Davies, Michael A., Herlyn, Meenhard, Winkler, Jeffrey, Koumenis, Constantinos, Amaravadi, Ravi K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934165/
https://ncbi.nlm.nih.gov/pubmed/24569374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70454
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