Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

Melanomas that result from mutations in the gene encoding BRAF often become resistant to BRAF inhibition (BRAFi), with multiple mechanisms contributing to resistance. While therapy-induced autophagy promotes resistance to a number of therapies, especially those that target PI3K/mTOR signaling, its r...

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Detalhes bibliográficos
Main Authors: Ma, Xiao-Hong, Piao, Sheng-Fu, Dey, Souvik, Mcafee, Quentin, Karakousis, Giorgos, Villanueva, Jessie, Hart, Lori S., Levi, Samuel, Hu, Janice, Zhang, Gao, Lazova, Rossitza, Klump, Vincent, Pawelek, John M., Xu, Xiaowei, Xu, Wei, Schuchter, Lynn M., Davies, Michael A., Herlyn, Meenhard, Winkler, Jeffrey, Koumenis, Constantinos, Amaravadi, Ravi K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934165/
https://ncbi.nlm.nih.gov/pubmed/24569374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70454
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