Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

The mechanisms by which maternal nutrient restriction (MNR) causes reduced fetal growth are poorly understood. We hypothesized that MNR inhibits placental mechanistic target of rapamycin (mTOR) and insulin/IGF-I signaling, down-regulates placental nutrient transporters, and decreases fetal amino aci...

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Päätekijät: Kavitha, Jovita V., Rosario, Fredrick J., Nijland, Mark J., McDonald, Thomas J., Wu, Guoyao, Kanai, Yoshikatsu, Powell, Theresa L., Nathanielsz, Peter W., Jansson, Thomas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Federation of American Societies for Experimental Biology 2014
Aiheet:
Research Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929672/
https://ncbi.nlm.nih.gov/pubmed/24334703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-242271
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